Littleton is a town in Halifax County, North Carolina, United States. The population was 692 at the 2000 census. It is part of the Roanoke Rapids, North Carolina Micropolitan Statistical Area.
Littleton was named after William Little, a state senator at the time of founding. In 1882, Littleton College for women was founded with an initial enrollment of eleven students. The college became relatively successful with a peak enrollment of 285 in 1908. On January 22, 1919, the college was destroyed by fire, and without an endowment, it was never rebuilt.
Littleton boast famous residents like Willis Alston, born near Littleton, United States Congressman from North Carolina and Civil Rights leader, SNCC founder Ella Baker, grew up at her grandmother's house in Littleton.