The San Gwann suburb is mostly made up of relatively modern buildings having been established as a parish only in 1965. However, the few scattered archeological remains found in the region suggest that San Gwann has an ancient history which is woven into the national history of Malta.

A number of factories also have established themselves in the San Gwann Industrial Estate which is found on the outskirts of this town. In the past ST Microelectronics used to carry out part of its work in San Gwann.

The parish church is dedicated to Our Lady of Lourdes.