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Big Pine Key is a census-designated place and unincorporated community in Monroe County, Florida, on an island of the same name in the Florida Keys. As of the 2000 census, the town had a total population of 5,032. The Blue Hole is an abandoned rock quarry that was used for nearby road fills and Henry Flagler's Overseas Railroad. The water it contains is mostly fresh and is used by various wildlife in the area, such as birds, snakes, alligators and iguanas. It is part of the National Key Deer Refuge. The primary grocery store is the Winn-Dixie, located in a shopping center just north of US-1. This same shopping center contains a Chinese restaurant, a Beall's Outlet, the visitor's center for the Key Deer Refuge, and a branch of the Monroe County Library (with WiFi internet access).

A CVS pharmacy is located along US-1, and has a good selection of sunblock and bug repellent, as well as remedies for insect bites. A small hardware store in this same area sells typical paint, hardware, tools and other goods needed to build/repair items around the home. They also carry a limited selection of parts for boat repair. Several bars and restaurants are available along the US-1 corridor, and the No Name Pub is located near the bridge to No Name Key in the NE part of the island. The nearest city of note is Marathon, approximately 23 miles (37km) "north" on US-1. Key West, a major shopping and cultural hub for the area, is about 30 miles (48 km) "south" on US-1. Accommodations are limited, though RV/camping and a limited number of motel-style units are available at the Big Pine Key Fishing Lodge on the far Southeast side of the island.

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