The Maldonado Department (Spanish: Departamento de Maldonado), with an area of 4,793 km² (1,851 square miles) and 140,192 inhabitants, is located to the southeast of Uruguay. Its capital is Maldonado.

Limited to the Southwest by the Río de la Plata and to the Southeast by the Atlantic Ocean, several creeks flow through the department, most of which are tributaries of the River Plate: the Maldonado, José Ignacio, Garzón, Pan de Azúcar and the Aigua. Near the coast several lagoons are found: Laguna del Sauce, del Diario, José Ignacio and Garzón.

The main crops are wheat, maize, sunflowers, oats, potatoes, among others, located in the south of the department. Fishing, as well as cattle and sheep raising have also a great importance in the department's economy. It is, along with Lavalleja, the main and most diversified mining area of the country producing (marble, metals, feldspars and construction materials), but it is currently underexploited. It has however, been the department with the fourth most significant mining activity, after Lavalleja, Canelones and Montevideo, with a production worth 4,642,123 dollars, according to 1999 data.